Elder statesman Tom Magliozzi turns 75 this year.
"My brother has always been 'work-averse," Ray Magliozzi, 63, said in a release. "Now, apparently, even the one hour a week is killing him."
NPR will continue to broadcast the show with material curated from the best of the more than 1,200 episodes recorded by the Magliozzis over the years, with occasional updates from the brothers.
"Sorry, detractors, we're s till going to be on the air!" Tom Magliozzi said in a blog post.
"Car Talk" was first broadcast in Boston in 1977 and picked up nationally by NPR 10 years later. It is heard weekly by an audience estimated at more than four million listeners..